5-ELISA ACE 2 Antigen Ref. No. 5D-55901

Description

The 5-ELISA ACE2 Antigen kit is a two-site enzyme immunoassay for measuring Angiotensin Converting Enzyme 2 (ACE2) antigen in plasma or in any biological fluid where it must be tested.

ACE2: The soluble form of the “Angiotensin Converting Enzyme 2” (ACE2) is present in plasma at very low concentrations in normal population and tends to increase ,in clinical circumstances with hypertension, as the result of a cell surface cleavage by ADAM 17. Soluble forms of ACE2 in plasma have been reported as good biomarkers for cardiovascular diseases/heart failure (see attached paper). In addition, ACE2 is a drug candidate under current evaluation to fight acute burdens from hypertension. The 5D Elisa can be used to monitor clinical evaluations. ACE2 is also the cell entry receptor for SARS-Cov-2, and tends to be elevated in severe cases, without any diagnostic value demonstrated at this stage for that application.

Antibodies to ACE2 have been reported in plasma from patients with Covid-19, and possibly associated to disease severity or long-lasting complications.