5-PROTEIN vWF, human, FVIII free
Ref. No. 5D-60175

5-PROTEIN vWF, human, FVIII free is Von Willebrand Factor (vWF) purified from citrated human plasma and free of FVIII. Supplied frozen in 100 μg aliquots in 25 mM sodium citrate, 0.1M glycine, 0.1M NaCl, pH 6.8. Store at -70°C.

Size 100 ug vial
Storage Requirements Store at -70°C. frozen, dry-ice shipment
Register to see prices
SKU: 5D-60175 Category:


Von Willebrand Factor (vWF) is a multimeric glycoprotein that circulates in plasma at a concentration of approximately 10 µg/mL, composed of 260,000 Da subunits held together by disulfide bonds. vWF exists in plasma in various forms, from as small as a dimer with a Mr equal to 520,000 Da to large multimers with Mr equal to 10,000,000 Da.

vWF plays a dual role in normal hemostasis. One role is to facilitate platelet plug formation by forming a bridge between Platelet Glycoprotein 1b and exposed collagen in the sub endothelium. Its second function is to act as a stabilizing cofactor for Factor VIII (FVIII), binding to and delivering functional FVIII. FVIII binds to the amino terminal portion of vWF subunit in a 1:1 molar ratio. Von Willebrand Disease (vWD) is characterized by a decrease in the ability for this bridge to be formed, or as a decrease in biological activity as a result of either a vWF protein deficiency or the presence of abnormal vWF protein.

vWF is purified from citrated human plasma. This preparation is free of FVIII.

Additional information


100 ug vial

Storage Requirements

Store at -70°C. Frozen, dry-ice shipment.

You may also like…